Director Shareholding

GlaxoSmithKline PLC
20 September 2004


                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


15 September 2004    6,175 Ordinary Shares in the Company were transferred to
                     Abacus (GSK) Trustees Limited, as trustee of the
                     GlaxoSmithKline Employee Trust ("GSK Trust") to rectify the
                     incorrect distribution of ordinary shares to Belgian
                     Performance Share Plan participants.


The Company was advised of this transaction on 20 September 2004.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

S M Bicknell
Company Secretary

20 September 2004

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