Director Shareholding

GlaxoSmithKline PLC
15 November 2004


                             Director's Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


12 November 2004    The Administrators of the SmithKline Beecham Employee 
                    Benefit Trust ("the Trust") notified the Company on 15 
                    November 2004 that 4,089 Ordinary shares in the Company had 
                    been sold on 9 November 2004 on behalf of participants in 
                    the GlaxoSmithKline Annual Investment Plan.

                    The Trust also notified the Company on 15 November that 
                    7,239 Ordinary Shares had been transferred to participants 
                    of the Annual Investment Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.


S M Bicknell
Company Secretary

15 November 2004



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