Director Shareholding

GlaxoSmithKline PLC
13 January 2005


                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


12 January 2005                  Abacus (GSK) Trustees Limited, as trustee of the
                                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), transferred
                                 1,046 Ordinary Shares in the Company to participants in the
                                 SmithKline Beecham Employee Share Option Plan 1991.





The Company was advised of these transactions on 13 January 2005.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



S M Bicknell,

Company Secretary



13 January 2005




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