Director Shareholding

GlaxoSmithKline PLC
14 January 2005

                              Director's Interests

I give below details of changes in interests in the Ordinary Shares and American
Depositary Receipts (ADRs) of GlaxoSmithKline plc in respect of the
under-mentioned directors:-


Dr J P Garnier      The Administrators of the GlaxoSmithKline Performance Share 
                    Plan notified the Company and Dr Garnier on 13 January 2005 
                    that his interest had notionally increased by 1,703.863 ADRs 
                    at a price of $44.15 per ADR following the notional 
                    re-investment of the dividend paid to shareholders on 06 
                    January 2005.

Dr T Yamada         The Administrators of the GlaxoSmithKline Performance Share 
                    Plan notified the Company and Dr Yamada on 13 January 2005 
                    that his interest had notionally increased by 511.159 ADRs 
                    at a price of $44.15 per ADR following the notional 
                    re-investment of the dividend paid to shareholders on 06 
                    January 2005.

Mr J D Coombe       The Administrators of the GlaxoSmithKline Performance Share 
                    Plan notified the Company and Mr Coombe on 13 January 2005 
                    that his interest had notionally increased by 1,036.225 
                    Ordinary Shares at a price of £11.93 per Ordinary Share 
                    following the notional re-investment of the dividend paid to 
                    shareholders on 06 January 2005.


The notional dividends accrued will be paid out in proportion to the percentage
of participants' Performance Share Plan holdings that vest following the end of
the relevant three year measurement period.


S M Bicknell
Company Secretary

14 January 2005


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