Director Shareholding

GlaxoSmithKline PLC 07 December 2004 Directors' Interests I give below details of changes in directors' interests in the Ordinary Shares of GlaxoSmithKline plc: The Administrators of the GlaxoSmithKline US Retirement Savings Plan ("the Plan") notified GlaxoSmithKline plc on 6 December 2004, that as a result of a movement in the fund on 3 December 2004, the number of Ordinary Share ADRs held by the fund had changed from 18,804,786 to 18,841,944 at an average price of $43.73 The Plan is a discretionary fund of which all employees or former employees of GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially interested in the shares held in the fund from time to time in the same way as other employees or former employees of GlaxoSmithKline plc and its subsidiaries. S M Bicknell Company Secretary 7 December 2004 This information is provided by RNS The company news service from the London Stock Exchange

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