Director Shareholding

GlaxoSmithKline PLC
04 November 2004



                              Directors' Interests


The Administrators of the GlaxoSmithKline Executive Supplemental Savings Plan
notified the Company and the under-mentioned Directors on 04 November 2004 of
changes in their interests in Ordinary Share ADRs arising from an increase in
their interests under the Annual Investment Plan feature following the
re-investment of the dividend paid to shareholders on 30 September 2004 at a
price of $43.73 per share:-


Dr J P Garnier                                                  310

Dr T Yamada                                                     200


S M Bicknell
Company Secretary



4 November 2004






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