Director Shareholding

GlaxoSmithKline PLC
02 February 2005

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

01 February 2005              Abacus (GSK) Trustees Limited ("the Trustees"), as 
                              trustee of the GlaxoSmithKline Employee Trust, 
                              ("the GSK Trust"), transferred 24,840 Ordinary 
                              Shares in the Company to participants in the 
                              SmithKline Beecham Mid Term Incentive Plan.

01 February 2005              The Trustees also transferred 2,010 Ordinary 
                              Shares in the Company to participants in the 
                              GlaxoSmithKline Performance Share Plan.

01 February 2005              The trustees also transferred 1,620 Ordinary 
                              Shares in the Company  to participants in the 
                              SmithKline Beecham Employee Share Option Plan 
                              1991.

The Company was advised of these transactions on 02 February 2005.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

S M Bicknell
Company Secretary

02 February 2005




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