Director Shareholding

GlaxoSmithKline PLC
10 December 2004



                              Director's Interests

I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £11.70 per Ordinary Share on 9
December 2004 through the Company's ShareReward Plan ("the Plan") which Mr
Coombe entered on 5 October 2001:


Mr J D Coombe       Acquisition of 11 Ordinary Shares under the partnership 
                    element of the Plan (personal contribution)

                    Acquisition of 11 Ordinary Shares under the matching element 
                    of the Plan (Company contribution)


Mr Coombe and the Company were advised of this information on 10 December 2004.


S M Bicknell
Company Secretary

10 December 2004


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