Director Shareholding

GlaxoSmithKline PLC
14 February 2005


                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


11 February 2005              Abacus (GSK) Trustees Limited ("the Trustees"), as trustee of
                              the GlaxoSmithKline Employee Trust, ("the GSK Trust"),
                              transferred 6,282 Ordinary Shares in the Company to
                              participants in the SmithKline Beecham Mid Term Incentive Plan.


11 February 2005              The Trustees also transferred 719,117 Ordinary Shares in the
                              Company to participants in the GlaxoSmithKline Performance
                              Share Plan.


11 February 2005              The Trustees also transferred 26,426 Ordinary Shares in the
                              Company  to participants in the SmithKline Beecham Employee
                              Share Option Plan 1991.


The Company was advised of these transactions on 14 February 2005.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe, are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell

Company Secretary


14 February 2005


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