Director Shareholding

GlaxoSmithKline PLC
15 February 2005


                              Director's Interests

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan, which is notionally held in GSK Ordinary
Share ADRs, the Administrators of the Plan notified GlaxoSmithKline plc and the
under-mentioned Directors on 15 February 2005 of an increase in the notional
allocation of Ordinary Share ADRs on 11 February 2005 at a price of $46.59 per
share:-


Dr J P Garnier                                  75

Dr T Yamada                                     10



S M Bicknell
Company Secretary
15 February 2005



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