Director Shareholding

GlaxoSmithKline PLC
15 February 2005

                              Director's Interests

I give below details of changes in interests in the American Depositary Shares
(ADSs) of GlaxoSmithKline plc in respect of the under-mentioned Director:-


Dr J-P Garnier        Exercise of options on 14 February 2005 over 44,475 ADSs 
                      granted on 15 November 1995, which would have lapsed on 
                      15 November 2005, under the SmithKline Beecham US 
                      Executive Share Option Plan 1989 at a price of $22.067443 
                      per ADS; and the exercise of options on 14 February 2005 
                      over 34,579 ADSs granted on 15 November 1995, which would 
                      have lapsed on 15 November 2005, under the SmithKline 
                      Beecham Employee Share Option Plan 1991 at a price of 
                      $22.067443 per ADS. The sale of 79,054 ADSs on 14 February
                      2005 at an average price of $47.7431.

                      Dr Garnier's total shareholding in the Company is 
                      432,663.20 ADSs, which includes 182,892 ADSs that have 
                      been earned but deferred under the share programmes 
                      operated by the Company. At the price at which the above 
                      options were exercised, Dr Garnier's holding is equivalent 
                      to more than 13 times his annual basic salary.

The Company was advised of these transactions on 14 February 2005.

S M Bicknell
Company Secretary

15 February 2005




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