Director Shareholding

GlaxoSmithKline PLC
07 February 2005

Director's Interests





I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




04 February 2005           The Administrators of the SmithKline Beecham Employee Benefit Trust notified
                           the Company on 07 February 2005 that 2,087 Ordinary shares in the Company had
                           been sold on 04 February 2005 on behalf of a participant in the SmithKline
                           Beecham Bonus Investment Plan at a price of £11.882 per share.



                           The Trust also notified the Company on 07 February 2005 that 3,012 Ordinary
                           shares had been transferred from the Trust to a participant in the SmithKline
                           Beecham Bonus Investment Plan.




The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.







S M Bicknell
Company Secretary



07 February 2005




                      This information is provided by RNS
            The company news service from the London Stock Exchange