Director Shareholding

GlaxoSmithKline PLC
08 April 2005


                             Directors' Interests

I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned Director, arising from the
purchase of Ordinary Shares on 07 April 2005 under a Single Company ISA at a
price of £12.41 per Ordinary Share:

Mr J S Heslop                                         5

The Company and Directors were advised of this information on 08 April 2005.


S M Bicknell
Company Secretary

08 April 2005


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