Director Shareholding

GlaxoSmithKline PLC
13 April 2005


                              Director's Interests

I give below details of changes in interests in the Ordinary Shares and American
Depositary Receipts (ADRs) of GlaxoSmithKline plc in respect of the
under-mentioned directors:-
                         
Dr J P Garnier           The Administrators of the GlaxoSmithKline Performance 
                         Share Plan notified the Company and Dr Garnier on 
                         13 April 2005 that his interest had notionally 
                         increased by 3819.757 ADRs at a price of $47.43 per ADR
                         following the notional re-investment of the dividend 
                         paid to shareholders on 07 April 2005.

Dr T Yamada              The Administrators of the GlaxoSmithKline Performance 
                         Share Plan notified the Company and Dr Yamada on 
                         13 April 2005 that his interest had notionally 
                         increased by 1145.928 ADRs at a price of $47.43 per ADR
                         following the notional re-investment of the dividend 
                         paid to shareholders on 07 April 2005.

Mr J S Heslop            The Administrators of the GlaxoSmithKline Performance 
                         Share Plan notified the Company and Mr Heslop on 
                         13 April 2005 that his interest had notionally 
                         increased by 148.919 Ordinary Shares at a price of
                         £12.49 per Ordinary Share following the notional 
                         re-investment of the dividend paid to shareholders on 
                         07 April 2005.


The notional dividends accrued will be paid out in proportion to the percentage
of participants' Performance Share Plan holdings that vest following the end of
the relevant three year measurement period.

S M Bicknell
Company Secretary

13 April 2005


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