Director Shareholding

GlaxoSmithKline PLC
15 April 2005



                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


14 April 2005          Abacus (GSK) Trustees Limited, as trustee of the 
                       GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                       transferred 8,934 Ordinary Shares in the Company to 
                       participants in the SmithKline Beecham Employee Share 
                       Option Plan 1991.


The Company was advised of this transaction on 15 April 2005.


The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell,
Company Secretary


15 April 2005





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