Director Shareholding

GlaxoSmithKline PLC
20 December 2004


                             Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

                        Abacus (GSK) Trustees Limited, as trustee of the
                        GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
   02 November 2004     transferred 3,263 Ordinary Shares in the Company to 
                        participants in the SmithKline Beecham Employee Share 
                        Option Plan 1991.

The Company was advised of these transactions on 20 December 2004.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

S M Bicknell,
Company Secretary

20 December 2004

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