Director Shareholding

GlaxoSmithKline PLC
21 February 2005


                              Director's Interests

Following a re-valuation of the cash element of the notional investment held
within the US Retirement Savings Plan, which is notionally held in GSK Ordinary
Share ADRs, the Administrators of the Plan notified GlaxoSmithKline plc and the
under-mentioned Directors on 18 February 2005 of an increase in the notional
allocation of Ordinary Share ADRs on 17 February 2005 at a price of $47.13 per
share:-


Dr J P Garnier                               52
Dr T Yamada                                  18


S M Bicknell
Company Secretary
21 February 2005


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