Director Shareholding

GlaxoSmithKline PLC
21 February 2005



                         Director's Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

                         
18 February 2005      The Administrators of the SmithKline Beecham Employee 
                      Benefit Trust notified the Company on 21 February 2005 
                      that 262 Ordinary shares in the Company had been sold on 
                      18 February 2005 on behalf of a participant in the 
                      SmithKline Beecham Bonus Investment Plan at a price of 
                      £12.402 per share.

                      The Trust also notified the Company on 21 February 2005 
                      that 855 Ordinary shares had been transferred from the 
                      Trust to a participant in the SmithKline Beecham Bonus 
                      Investment Plan.


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.


S M Bicknell
Company Secretary

21 February 2005



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