Director Shareholding

GlaxoSmithKline PLC
22 February 2005


                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.
                      
21 February 2005      Abacus (GSK) Trustees Limited, as trustee of the 
                      GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                      transferred 3,095 Ordinary Shares in the Company to 
                      participants in the SmithKline Beecham Employee Share 
                      Option Plan 1991.


The Company was advised of these transactions on 22 February 2005.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell,
Company Secretary

22 February 2005



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