Director Shareholding

GlaxoSmithKline PLC
07 January 2005



                              Directors' Interests



I give below details of changes in interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned Directors or connected
persons, arising from the purchase of Ordinary Shares on 06 January 2005 under a
Single Company ISA at a price of £12.39 per Ordinary Share:


Mr J D Coombe                                  3


Mrs G A Coombe                                 3
  (wife of Mr J D Coombe)


Sir Peter Job                                  6


The Company and Directors were advised of this information on 07 January 2005.




S M Bicknell

Company Secretary



07 January 2005




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