Director Shareholding

GlaxoSmithKline PLC
07 March 2005








                                 Director's Interests





I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




03 March 2005              The Administrators of the SmithKline Beecham Employee Benefit Trust ("The
                           Trust") notified the Company on 07 March 2005 that 231 Ordinary shares in the
                           Company had been sold on behalf of a participant in the GlaxoSmithKline Annual
                           Investment Plan at a price of £13.152 per share.


                           The Trust also notified the Company on 07 March 2005 that 798 Ordinary shares
                           had been transferred from the Trust to a participant in the GlaxoSmithKline
                           Annual Investment Plan.







The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.







S M Bicknell

Company Secretary



07 March 2005




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