Director Shareholding

GlaxoSmithKline PLC
10 March 2005





                              Director's Interests


I give below details of a change in the interests in Ordinary Shares of
GlaxoSmithKline plc in respect of the undermentioned Director arising from the
purchase of Ordinary Shares at a price of £12.8255 per Ordinary Share on 9 March
2005 through the Company's ShareReward Plan ("the Plan") which Mr Coombe entered
on 5 October 2001:


Mr J D Coombe      Acquisition of 10 Ordinary Shares under the partnership 
                   element of the Plan (personal contribution)

                   Acquisition of 10 Ordinary Shares under the matching element 
                   of the Plan (Company contribution)



Mr Coombe and the Company were advised of this information on 10 March 2005.






S M Bicknell
Company Secretary


10 March 2005


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