Director Shareholding

GlaxoSmithKline PLC
10 March 2005



                              Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

09 March 2005               Abacus (GSK) Trustees Limited, as trustee of the 
                            GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                            transferred 4,908 Ordinary Shares in the Company to 
                            participants in the SmithKline Beecham Employee
                            Share Option Plan 1991.

The Company was advised of these transactions on 10 March 2005.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J D Coombe are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

S M Bicknell,
Company Secretary

10 March 2005


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