Director Shareholding

GlaxoSmithKline PLC
21 March 2005




Directors' Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




18 March 2005              The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on the 21 March 2005 that 256,018 Ordinary shares
                           had been purchased for participants in the SmithKline Beecham Annual
                           Investment Plan at a price of £12.25 per share.



The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, John Coombe is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.







S M Bicknell

Company Secretary



21 March 2005




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