Director Shareholding

GlaxoSmithKline PLC
21 March 2005


                              Director's Interests


I give below details of a change in the interests in the Ordinary Shares of
GlaxoSmithKline plc in respect of the under-mentioned director:-

Mr J D Coombe      The transfer by Mr Coombe on 18th March 2005 of a total of 
                   50,000 shares in GlaxoSmithKline plc to his wife, Mrs G A 
                   Coombe.


The Company was advised of this transaction on 21st March 2005


SM Bicknell

Company Secretary



21st March 2005


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