Director Shareholding

GlaxoSmithKline PLC
18 April 2005


                            Director's Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

                    
15 April 2005        The Administrators of the SmithKline Beecham Employee 
                     Benefit Trust ("the Trust") notified the Company on 
                     18 April 2005 that following reinvestment of the cash 
                     dividend paid to shareholders on 07 April 2005, 1,228 
                     Ordinary Shares in the Company had been purchased for 
                     participants in the SmithKline Beecham Bonus Investment 
                     Plan at a price of £12.747 per share.

15 April 2005        The Administrators of the Trust also notified the Company 
                     on 18 April 2005 that following reinvestment of the cash 
                     dividend paid to shareholders on 07 April 2005, 8,702 
                     Ordinary Shares in the Company had been purchased for 
                     participants in the GlaxoSmithKline Annual Investment Plan 
                     at a price of £12.747 per share.



The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Julian Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.

S M Bicknell
Company Secretary

18 April 2005

                      This information is provided by RNS
            The company news service from the London Stock Exchange