Director Shareholding

GlaxoSmithKline PLC
23 May 2005



Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc:

               The Administrators of the GlaxoSmithKline US Retirement Savings 
               Plan ("the Plan") notified GlaxoSmithKline plc on 23 May 2005, 
               that as a result of a movement in the fund on 19 May 2005, the 
               number of Ordinary Share ADRs held by the fund had changed from 
               18,264,444 to 18,243,806 at an average price of $49.95.

The Plan is a discretionary fund of which all employees or former employees of
GlaxoSmithKline plc and its subsidiaries are potential beneficiaries. Two of the
Company's directors, Dr J P Garnier and Dr T Yamada are therefore potentially
interested in the shares held in the fund from time to time in the same way as
other employees or former employees of GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary

23 May 2005


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