Director Shareholding

GlaxoSmithKline PLC
23 May 2005





Director's Interests





I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




18 May 2005                The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 23 May 2005 that 91 Ordinary shares in the
                           Company had been sold on behalf of a participant in the GlaxoSmithKline Bonus
                           Investment Plan at a price of £13.70 per share.



                           The Administrators of the Trust also notified the Company on 23 May 2005 that
                           329 Ordinary shares had been transferred from the Trust to a participant in
                           the GlaxoSmithKline Bonus Investment Plan.



                           The Administrators of the Trust also notified the Company on 23 May 2005 that
                           188 Ordinary shares in the Company had been sold on behalf of a participant in
                           the GlaxoSmithKline Annual Investment Plan at a price of £13.70 per share.



                           The Trust also notified the Company on 23 May 2005 that 682 Ordinary shares
                           had been transferred from the Trust to participants in the GlaxoSmithKline
                           Annual Investment Plan.
18 May 2005








The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J S Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.





S M Bicknell

Company Secretary



23 May 2005




                      This information is provided by RNS
            The company news service from the London Stock Exchange