Director Shareholding

GlaxoSmithKline PLC
25 May 2005




                              Directors' Interests



I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


24 May 2005                   Abacus (GSK) Trustees Limited, as trustee of the
                              GlaxoSmithKline Employee Trust, ("the GSK Trust"), transferred
                              5,024 Ordinary Shares in the Company to participants in the
                              SmithKline Beecham Employee Share Option Plan 1991.


The Company was advised of these transactions on 25 May 2005.



The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop, are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.



S M Bicknell

Company Secretary



25 May 2005




                      This information is provided by RNS
            The company news service from the London Stock Exchange