Director Shareholding

GlaxoSmithKline PLC
09 June 2005

                              Directors' Interests

I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.

08 June 2005     Abacus (GSK) Trustees Limited, as trustee of the
                 GlaxoSmithKline Employee Trust, ("the GSK Trust"), transferred
                 6,450 Ordinary Shares in the Company to participants in the
                 SmithKline Beecham Employee Share Option Plan 1991.

The Company was advised of these transactions on 09 June 2005.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop, are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.


S M Bicknell
Company Secretary



09 June 2005




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