Director Shareholding

GlaxoSmithKline PLC
13 June 2005





Director's Interests





I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.




07 June 2005               The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 13 June 2005 that 606 Ordinary shares in the
                           Company had been sold on behalf of a participant in the GlaxoSmithKline Annual
                           Investment Plan at a price of £13.7821 per share.



                           The Administrators of the Trust also notified the Company on 13 June 2005 that
                           620 Ordinary shares had been transferred from the Trust to a participant in
                           the GlaxoSmithKline Annual Investment Plan.



                           The Administrators of the Trust also notified the Company on 13 June 2005 that
                           1,027 Ordinary shares in the Company had been sold on behalf of a participant
                           in the GlaxoSmithKline Annual Investment Plan at a price of £13.6621 per
                           share.



                           The Administrators of the Trust also notified the Company on 13 June 2005 that
                           3,392 Ordinary shares had been transferred from the Trust to a participant in
09 June 2005               the GlaxoSmithKline Annual Investment Plan.








The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J S Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.





S M Bicknell

Company Secretary



13 June 2005




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