Director Shareholding

GlaxoSmithKline PLC
27 June 2005


                              Director's Interests


I give below details of changes in directors' interests in the Ordinary Shares
of GlaxoSmithKline plc.


20 June 2005               The Administrators of the SmithKline Beecham Employee Benefit Trust ("the
                           Trust") notified the Company on 27 June 2005 that 2,495 Ordinary shares in the
                           Company had been sold on behalf of a participant in the GlaxoSmithKline Bonus
                           Investment Plan at a price of £13.3035 per share.



                           The Administrators of the Trust also notified the Company on 27 June 2005 that
                           3,535 Ordinary shares had been transferred from the Trust to a participant in
                           the GlaxoSmithKline Bonus Investment Plan.



20 June 2005               The Administrators of the Trust also notified the Company on 27 June 2005 that
                           2,958 Ordinary shares in the Company had been sold on behalf of a participant
                           in the GlaxoSmithKline Annual Investment Plan at a price of £13.3035 per
                           share.



                           The Trust also notified the Company on 27 June 2005 that 4,193 Ordinary shares
                           had been transferred from the Trust to participants in the GlaxoSmithKline
                           Annual Investment Plan.



The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J S Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



S M Bicknell
Company Secretary

27 June 2005


                      This information is provided by RNS
            The company news service from the London Stock Exchange END

RDSFRMFTMMTTBMA