Holding in Company

GlaxoSmithKline PLC
10 September 2001

       GLAXOSMITHKLINE plc - Notification of Major Interests in Shares

GlaxoSmithKline plc (the Company) has today received notification from
Barclays PLC, through its subsidiary Barclays Bank PLC, in compliance with
Part VI of the Companies Act 1985 (as amended), that on 5 September 2001 it
had the following interests in the Company's Ordinary Shares of 25 pence:

Registered Holder                                          Current shareholding

MSTC Nominees Ltd                                                       138,725
MSTC Nominees Ltd                                                         2,100
MSTC Nominees Ltd                                                       560,069
Barclays Capital Nominees Limited                                     4,649,080
Bank of Ireland Nominees Limited A/C 289166                              55,596
Bank of Ireland Nominees Limited A/C 73520                              735,460
Dematerialised                                                           53,404
Chase Nominees Limited A/C 16331                                      2,272,867
Chase Nominees Limited A/C 16338                                        356,113
Chase Nominees Limited A/C 16341                                      6,291,376
Chase Nominees Limited A/C 16342                                        635,340
Chase Nominees Limited A/C 16344                                        329,780
Chase Nominees Limited A/C 16345                                        623,554
Chase Nominees Limited A/C 16376                                      1,107,100
Chase Nominees Limited A/C 16400                                     57,810,952
Chase Nominees Limited A/C 16530                                     14,235,649
Chase Nominees Limited A/C 18408                                        763,065
Chase Nominees Limited A/C 20947                                     12,451,594
DEM69                                                                   854,860
Barclays Bank Trust Co Ltd & third party nominee                          4,371
Barclays Bank Trust Co Ltd as executor                                   13,253
*** Unknown ***                                                           7,548
Zeban Nominees Limited                                                      955
Phildrew Nominees Limited                                               334,395
Barclays Bank Trust Co Ltd - IMA                                         24,203
Chase Manhattan Bank London                                          37,085,815
Twenty Nine Gracechurch Street Nominees Limited A/C 5782A             9,139,623
CEDE & Co                                                                87,326
Barclays Bank Trust Company Ltd                                             448






*** Unknown ***                                                       3,097,244
*** Unknown ***                                                          97,712
*** Unknown ***                                                         225,163
*** Unknown ***                                                          47,747
*** Unknown ***                                                         102,439
*** Unknown ***                                                         114,005
*** Unknown ***                                                          17,050
Barclays Bank Trust Co Ltd and another                                  221,925
*** Unknown ***                                                      39,271,579
Nutraco Nominees Limited                                                784,000
TOTAL                                                               194,603,485



This total holding represented 3.11 per cent of the issued share capital of
the Company.







S M Bicknell

Company Secretary

10 September 2001