Holding(s) in Company

GlaxoSmithKline PLC
19 May 2006

GLAXOSMITHKLINE plc - Notification of Major Interests in Shares

GlaxoSmithKline plc (the Company) yesterday received notification from Barclays
plc in compliance with Part VI of the Companies Act 1985 (as amended), that on
12 May 2006 it had the following interests in the Company's Ordinary Shares of
25 pence:

Registered Holder                                                                    Current shareholding
Barclays Global Investors Japan Ltd                                                             4,322,451
Barclays Global Investors Ltd                                                                  80,593,667
Gerrard Ltd                                                                                    16,658,128
Barclays Private Bank and Trust Ltd                                                               219,460
Barclays Global Investors Japan Trust & Banking                                                 6,910,352
Barclays Private Bank and Trust Ltd                                                                 9,775
Barclays Global Investors Canada Ltd                                                              418,322
Barclays Capital Securities Ltd                                                                16,269,211
Barclays Global Investors, N.A.                                                                66,543,126
Barclays Bank Trust Company Ltd                                                                   981,245
Barclays Global Fund Advisors                                                                  18,080,256
Barclays Life Assurance Co Ltd                                                                  9,961,175
Barclays Private Bank and Trust Ltd                                                               200,000
Barclays Capital Inc                                                                            8,655,483
Barclays Global Investors Australia Ltd                                                         2,271,916
Barclays Private Bank Ltd                                                                       1,089,395
TOTAL                                                                                         233,183,962


Barclays plc's total holding had increased from 3.80 per cent to 4.01 per cent
of the issued share capital of the Company (excluding shares held in Treasury).

In addition the Company also received notification from Barclays plc in
compliance with Part VI of the Companies Act 1985 (as amended), that on 15 May
2006 it had the following interests in the Company's Ordinary Shares of 25
pence:


Registered Holder                                                                    Current shareholding
Barclays Private Bank and Trust Ltd                                                               200,000
Barclays Private Bank and Trust Ltd                                                                 9,775
Barclays Global Fund Advisors                                                                  18,120,438
Barclays Life Assurance Co Ltd                                                                  9,961,175
Barclays Private Bank and Trust Ltd                                                               219,460
Barclays Global Investors Japan Ltd                                                             4,322,451
Barclays Global Investors Australia Ltd                                                         2,312,855
Gerrard Ltd                                                                                    16,653,507
Barclays Bank Trust Company Ltd                                                                   980,653
Barclays Global Investors Ltd                                                                  80,703,260
Barclays Capital Securities Ltd                                                                 7,681,460
Barclays Private Bank Ltd                                                                       1,088,730
Barclays Capital Inc                                                                              255,049
Barclays Global Investors, N.A.                                                                67,097,436
Barclays Global Investors Canada Ltd                                                              418,322
Barclays Global Investors Japan Trust & Banking                                                 6,910,352
TOTAL                                                                                         216,934,923


Barclays plc's total holding has decreased from 4.01 per cent to 3.73 per cent
of the issued share capital of the Company (excluding shares held in Treasury).


S M Bicknell
Company Secretary

19 May 2006


                      This information is provided by RNS
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