Transaction in Own Shares

GlaxoSmithKline PLC
12 December 2005



GlaxoSmithKline plc (the "Company") announces that in accordance with the
authority granted by shareholders at the Company's Annual General Meeting on
25th May 2005 it purchased 800,000 of its Ordinary shares of 25 pence each
("shares") on 12 December 2005 at a price of 1440.99 pence per share.

The Company intends to hold these shares in Treasury.

Following the purchase of these shares, the Company holds 135,508,000 of its
shares in Treasury and has 5,823,910,917 shares in issue (excluding Treasury
shares).

This announcement does not constitute, or form part of, an offer or any
solicitation of an offer to purchase or subscribe for securities in any
jurisdiction.






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