Transaction in Own Shares

GlaxoSmithKline PLC
21 December 2004



GlaxoSmithKline plc (the "Company") announces that in accordance with the
authority granted by shareholders at the Company's Annual General Meeting on
17th May 2004 it purchased 500,000 of its Ordinary Shares of 25 pence each
("Shares") on 21 December 2004 at a price of 1180.37 pence per Share.

The Company intends to hold these Shares in treasury.

Following the purchase of these Shares, the Company holds 69,948,000 of its
shares in treasury and has 5,867,561,608 Shares in issue (excluding treasury
shares).

This announcement does not constitute, or form part of, an offer or any
solicitation of an offer to purchase or subscribe for securities in any
jurisdiction.



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