Transaction in Own Shares

GlaxoSmithKline PLC
10 November 2006

GlaxoSmithKline plc (the "Company") announces that in accordance with the
authority granted by shareholders at the Company's Annual General Meeting on 17
May 2006 it purchased 1,825,000 of its Ordinary shares of 25 pence each
("shares") on 10 November 2006 at a price of 1359.25 pence per share.

The Company intends to hold these shares in Treasury.

Following the purchase of these shares, the Company holds 218,514,678
of its shares in Treasury and has 5,770,641,223 shares in issue (excluding
Treasury shares).

This announcement does not constitute, or form part of, an offer or any
solicitation of an offer to purchase or subscribe for securities in any
jurisdiction.



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