Transaction in Own Shares

GlaxoSmithKline PLC
16 November 2006



GlaxoSmithKline plc (the "Company") announces that in accordance with the
authority granted by shareholders at the Company's Annual General Meeting on 17
May 2006 it purchased 1,100,000 of its Ordinary shares of 25 pence each
("shares") on 16 November 2006 at a price of 1368.53 pence per share.

The Company intends to hold these shares in Treasury.

Following the purchase of these shares, the Company holds 221,589,678 of its
shares in Treasury and has 5,767,692,883 shares in issue (excluding Treasury
shares).

This announcement does not constitute, or form part of, an offer or any
solicitation of an offer to purchase or subscribe for securities in any
jurisdiction.












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