Transaction in Own Shares

GlaxoSmithKline PLC
10 March 2006




                              GlaxoSmithKline PLC



GlaxoSmithKline plc (the "Company") announces that in accordance with the
authority granted by shareholders at the Company's Annual General Meeting on 25
May 2005 it purchased 315,000 of its Ordinary shares of 25 pence each ("shares")
on 10 March 2006 at a price of 1562.47 pence per share.



The Company intends to hold these shares in Treasury.



Following the purchase of these shares, the Company holds 149,114,678 of its
shares in Treasury and has 5,821,867,034 shares in issue (excluding Treasury
shares).



This announcement does not constitute, or form part of, an offer or any
solicitation of an offer to purchase or subscribe for securities in any
jurisdiction.





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