Director/PDMR Shareholding

Intl. Biotechnology Trust PLC
20 December 2007

   NOTIFICATION OF TRANSACTIONS OF DIRECTORS, PERSONS DISCHARGING MANAGERIAL
                      RESPONSIBILITY OR CONNECTED PERSONS



1. Name of the issuer

International Biotechnology Trust plc

2. State whether the notification relates to (i) a transaction notified in
accordance with DR 3.1.4R(1)(a); or (ii) DR 3.1.4(R)(1)(b) a disclosure made in
accordance with section 324 (as extended by section 328) of the Companies Act
1985

Both (i) and (ii)

3. Name of person discharging managerial responsibility/director

Alex Hammond-Chambers

4. State whether notification relates to a person connected with a person
discharging managerial responsibilities/director named in 3 and identify the
connected person

Notification not in relation to a person connected to the Director named in 3
above

5. Indicate whether the notification is in respect of a holding of the person
referred to in 3 or 4 above or in respect of a non-beneficial interest

In respect of holding of Director referred to in 3 above

Beneficial interest

6. Description of shares (including class), debentures or derivatives or
financial instruments relating to shares

Ordinary shares of 25 pence each

7. Name of registered shareholders(s) and, if more than one, the number of
shares held by each of them

Adam & Company (Nominees) Limited



8. State the nature of the transaction

Purchase of Shares

9. Number of shares, debentures or financial instruments relating to shares
acquired

15,000 Ordinary Shares

10. Percentage of issued class acquired (treasury shares of that class should
not be taken into account when calculating percentage)

0.0212%

11. Number of shares, debentures or financial instruments relating to shares
disposed

Nil

12. Percentage of issued class disposed (treasury shares of that class should
not be taken into account when calculating percentage)

N/A

13. Price per share or value of transaction

132.75 pence per share

14. Date and place of transaction

19 December 2007 - London Stock Exchange

15. Total holding following notification and total percentage holding following
notification (any treasury shares should not be taken into account when
calculating percentage)

40,000 Ordinary Shares, being 0.056% of the issuer's issued Ordinary share
capital

16. Date issuer informed of transaction

19 December 2007

17. Any additional information

None

18. Name of contact and telephone number for queries

Louise Richard - 020 7658 6501

Name and signature of duly authorised officer of issuer responsible for making
notification

Louise Richard

For and behalf of Schroder Investment Management Limited

Secretary to International Biotechnology Trust plc

Date of notification

20 December 2007


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