Director Shareholding

Intl. Biotechnology Trust PLC
26 January 2001

                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

INTERNATIONAL BIOTECHNOLOGY TRUST PLC


2)  NAME OF DIRECTOR

PETER COLLACOTT

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

DIRECTOR

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

REGISTERED IN OWN NAME

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary

TENDER OFFER

7)  Number of shares/amount of
    stock acquired

-

8)   ( - %)
    of issued Class


9)  Number of shares/amount
    of stock disposed

6,183

10)  (0.013%)
    of issued Class


11) Class of security

ORDINARY SHARES


12) Price per share

280.89P

13) Date of transaction

20 JANUARY 2001

14) Date company informed

10 JANUARY 2001

15) Total holding following this notification

6,183 ORDINARY SHARES

16) Total percentage holding of issued class following this notification

0.013

     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant



18) Period during which or date on which exercisable



19) Total amount paid (if any) for grant of the option



20) Description of shares or debentures involved: class, number.



21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise



22) Total number of shares or debentures over which options held
    following this notification



23) Any additional information



24) Name of contact and telephone number for queries

JOHN SPEDDING
020 7658 3206

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification     26 JANUARY 2001



                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

INTERNATIONAL BIOTECHNOLOGY TRUST PLC


2)  NAME OF DIRECTOR

JOHN GREEN-ARMYTAGE

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

DIRECTOR

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

REGISTERED IN OWN NAME

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary

TENDER OFFER

7)  Number of shares/amount of
    stock acquired

-

8)   ( - %)
    of issued Class


9)  Number of shares/amount
    of stock disposed

17,500

10)  (0.036%)
    of issued Class


11) Class of security

ORDINARY SHARES


12) Price per share

280.89P

13) Date of transaction

20 JANUARY 2001

14) Date company informed

10 JANUARY 2001

15) Total holding following this notification

15,000 ORDINARY SHARES (NON BENEFICIAL)
17,500 ORDINARY SHARES (BENEFICIAL)

16) Total percentage holding of issued class following this notification

0.036

     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant



18) Period during which or date on which exercisable



19) Total amount paid (if any) for grant of the option



20) Description of shares or debentures involved: class, number.



21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise



22) Total number of shares or debentures over which options held
    following this notification



23) Any additional information



24) Name of contact and telephone number for queries

JOHN SPEDDING
020 7658 3206

25) Name and signature of authorised company official responsible for
    making this notification

   Date of Notification     26 JANUARY 2001