Holding in Company

Intl. Biotechnology Trust PLC 24 November 2000 LETTER TO COMPANY ANNOUNCEMENTS OFFICE SUBSTANTIAL SHARE INTEREST NOTIFICATION We are writing to advise you that the Company was notified on 24 November 2000, that The Lucas Pensions Trust no longer has a notifiable interest in the Company's ordinary shares, following a reduction in their interest on 17 November 2000. LETTER FROM INTL. BIOTECHNOLOGY TRUST PLC
UK 100

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