Holding in Company

Intl. Biotechnology Trust PLC
4 January 2001



Letter to Company Announcements

               SUBSTANTIAL SHARE INTEREST NOTIFICATION

We are writing to advise you that the Company was notified on 2 January 2001,
that Rothschild Asset Management Limited has a beneficial interest in 3,985,334
of the Company's ordinary shares, being 4.33% of the issued share capital.

Letter from International Biotechnology Trust plc