Holding(s) in Company

Intl. Biotechnology Trust PLC
05 February 2003

5 February 2003

By Facsimile



RNS

Old Broad Street

London

EC2N 1HP



Dear Sirs


                    Substantial Share Interest Notification




We are writing to advise that the Company was notified on 5 February 2003 that,
following purchases of 500,000 ordinary shares East Riding of Yorkshire Council
has an interest in 1,750,000 ordinary shares of 25p each, representing 3.60% of
the 48,615,467 shares in issue.




Yours faithfully,





John Spedding

For SCHRODER INVESTMENT MANAGEMENT LIMITED

Secretaries




                      This information is provided by RNS
            The company news service from the London Stock Exchange