Holding(s) in Company

Intl. Biotechnology Trust PLC
02 April 2004

                                                                 2 April 2004

                    Substantial Share Interest Notification

We are writing to advise that the Company was notified on 2 April 2004 that
Deutsche Bank AG and its subsidiary companies have a notifiable interest in
4,975,000 ordinary shares of 25p each, representing 10.40% of the 47,815,467
shares in issue.


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Enquiries:


John Spedding
Schroder Investment Management Limited                       020 7658 3206







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