Holding(s) in Company

Intl. Biotechnology Trust PLC
29 April 2004



                                                                   29 April 2004



                    Substantial Share Interest Notification


We are writing to advise that the Company was notified on 29 April 2004 that,
following a sale of 480,000 ordinary shares on 28 April 2004, East Riding of
Yorkshire Council has an interest in 1,000,000 ordinary shares of 25p each,
representing 2.09% of the 47,815,467 shares in issue.



Enquiries:

Neil Olofsson

Schroder Investment Management Limited                 Tel: [phone]


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