Holding(s) in Company

Intl. Biotechnology Trust PLC
18 August 2004

                                                               18 August 2004



                    Substantial Share Interest Notification


The Company was notified on 17 August 2004 that Prudential plc and certain of
its subsidiary companies have a notifiable interest in 2,995,024 ordinary shares
of 25p each, representing 6.26% of the 47,815,467 shares in issue.


The date of the transaction was not disclosed.


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Enquiries:


John Spedding
Schroder Investment Management Limited                        020 7658 3206












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