Holding(s) in Company

Intl. Biotechnology Trust PLC
07 August 2007


TR-1(i):               Notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing   International Biotechnology Trust plc
shares to which voting rights are attached(ii):
2. Reason for the notification     (please tick the appropriate box or boxes)
An acquisition or disposal of voting rights
An acquisition or disposal of financial instruments which may result in the acquisition of
shares already issued to which voting rights are attached
An event changing the breakdown of voting rights
Other (please specify): Increase of Total Voting Rights Figure                                   X
3. Full name of person(s) subject to the notification obligation                   HBOS plc
(iii):
4. Full name of shareholder(s) (if different from 3.)(iv):                 See Section 9.
5. Date of the transaction (and date on which the threshold is                   31 July 2007
crossed or reached if different)(v):
6. Date on which issuer notified:                                               1 August 2007
7. Threshold(s) that is/are crossed or reached:                         Decrease to below 3% (Direct
                                                                               Interests)
8. Notified details:


A: Voting rights attached to shares
Class/type of     Situation previous to the Resulting situation after the triggering transaction(vii)
shares            Triggering transaction
                  (vi)
 if possible      Number of   Number of     Number of    Number of voting rights   % of voting rights
using the ISIN    Shares      Voting Rights shares       ix
CODE                          viii          Direct       Direct  x    Indirect xi  Direct     Indirect


Ord 25p Shares    2,184,907   2,184,907     1,984,907    1,984,907    1,083,725    2.812%     1.535%

ISIN

GB0004559349


B: Financial Instruments
Resulting situation after the triggering transaction xii
Type of financial     Expiration date Exercise/ Conversion      Number of voting rights    % of voting
instrument            xiii            Period/ Date xiv          that may be acquired if    rights
                                                                the instrument is
                                                                exercised/ converted.


N/A


Total (A+B)
Number of voting rights                             % of voting rights


3,068,632                                           4.347%


9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively
held, if applicable xv:
N/A - holdings below reportable threshold


Proxy Voting:
10. Name of the proxy holder:                                                       N/A
11. Number of voting rights proxy holder will cease to hold:                        N/A
12. Date on which proxy holder will cease to hold voting rights:                    N/A


13. Additional information:                                                Based on Total voting rights:
                                                                                    70,592,664

                                                                        Date of notification: 8 August 2007
14. Contact name:                                                                 Louise Richard

                                                                      Schroder Investment Management Limited
15. Contact telephone number:                                                      020 7658 6501



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