Portfolio Update

Intl. Biotechnology Trust PLC
04 March 2008


                     International Biotechnology Trust plc


The Board of International Biotechnology Trust plc announces that the top ten
holdings as a percentage of net assets at Friday 29 February 2008 are:


Celgene Com USD0.01                                                      5.65
CSL NPV                                                                  5.32
Gilead Sciences Com USD0.001                                             5.10
Applera-Celera Genomics Group Com USD0.01                                3.67
Oxagen Ltd Series B Pref Shs                                             3.38
Barr Pharmaceuticals Com USD0.01                                         3.23
Shire Ord GBP0.05                                                        3.00
Medicines Company Com USD0.001                                           2.69
Alexion Pharmaceuticals Com USD0.0001                                    2.52
Acambis Ord GBP0.10                                                      2.51


                             By Order of the Board

                     Schroder Investment Management Limited

                               Company Secretary



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Enquiries :

International Biotechnology Trust plc

Tina Watts 020 7658 3581


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