Annual Information Update

Phytopharm PLC 01 February 2008 Phytopharm plc Annual Information Update Phytopharm plc (the Company) announces that, in accordance with the requirements of Prospectus Rule 5.2 issued by the Financial Services Authority, and following publication of the Annual Report on 16 January 2008, the following information has been published or made available to the public between 13 January 2007 and 1 February 2008 inclusive, in compliance with laws and rules dealing with the regulation of securities, issuers of securities and securities markets. For the purpose of this update, only references to the information are provided. Full copies of each item can be found at the locations specified below. In accordance with the provisions of Article 27.3 of the Prospectus Directive Regulations, we confirm that to the best of our knowledge, information relating to 'Holdings in Company' and 'Director/PDMR Shareholdings' is up to date at the date of this announcement, but it is acknowledged that such disclosures may, at any time, become out of date, due to changing circumstances. 1. Announcements made via Regulatory Information Services All documents listed below were published via a regulatory information service on the dates indicated: Date of publication Title 21 January 2008 $1.16m funding for Cogane(TM) 16 January 2008 Publication of 2007 annual report and accounts 10 January 2008 Director/PDMR shareholding 2 January 2008 Total Voting rights 14 December 2007 Director/PDMR shareholding 4 December 2007 Total Voting Rights 29 November 2007 Second price monitoring extension 29 November 2007 Price monitoring extension 29 November 2007 Final Results 27 November 2007 Holding in Company 23 November 2007 Appointment of Adviser 9 November 2007 Director/PDMR shareholding 29 October 2007 Block Listing Cancellation 29 October 2007 Additional Listing 3 October 2007 New Accounting Reference Date 24 September 2007 Joint Development Agreement 18 September 2007 Block Listing Interim Review 14 September 2007 Director/PDMR shareholding 14 September 2007 Director/PDMR shareholding 6 August 2007 Director/PDMR shareholding 6 August 2007 Director/PDMR shareholding 30 July 2007 Research Update 26 June 2007 Collaboration & Licence Agreement 20 June 2007 Notification of Board change 14 June 2007 Result of EGM 11 June 2007 Holding(s) in company 7 June 2007 Director/PDMR shareholding 5 June 2007 Research Update 22 May 2007 Notification of EGM 17 May 2007 Research Update 9 May 2007 Director/PDMR shareholding 9 May 2007 Director/PDMR shareholding 9 May 2007 Director/PDMR shareholding 9 May 2007 Director/PDMR shareholding 1 May 2007 Block Listing Interim Review 1 May 2007 Interim results 24 April 2007 Price Monitoring Extension 20 April 2007 Notice of results 16 April 2007 Product Launch 2 April 2007 Total Voting Rights 29 March 2007 Result of AGM 26 March 2007 Product Launch 19 March 2007 Block Listing Interim Review 7 March 2007 Holding(s) in company 7 March 2007 Holding(s) in company 2 March 2007 Notification of AGM 1 March 2007 Second price monitoring extension 1 March 2007 Price monitoring extension 1 March 2007 Placing of New Ordinary Shares 15 January 2007 Price monitoring extension 15 January 2007 Annual Information Update 2. Documents published or sent to Shareholders or filed with the UK Listing Authority or submitted to the FSA 16 January 2008 Annual Report 2007 29 October 2007 Application for admission of securities to the Official List 29 October 2007 Form 1 Application for admission of securities to trading 22 May 2007 Notice of Extraordinary General Meeting 18 May 2007 Interim Report 2007 2 March 2007 Application for admission of securities to the Official List 2 March 2007 Form 1 Application for admission of securities to trading 2 March 2007 Notice of Annual General Meeting Certain documents submitted to the FSA can be viewed at the Document Viewing Facility situated at the Financial Services Authority, 25 The North Colonade, Canary Wharf, London E14 5HS The Interim and Annual reports are also available on the Company's website www.phytopharm.com 3. Documents filed at Companies House The Company has submitted the following filings to Companies House: 9 January 2008 Form 88(2) - Return of Allotment of Shares 17 December 2007 Form 363 Annual Return 11 December 2007 Form 88(2) - Return of Allotment of Shares 9 November 2007 Form 88(2) - Return of Allotment of Shares 3 October 2007 Form 225 - Change of Accounting Date 31 July 2007 Form 288(a) Appointment of Director - Mr Alistair Taylor 31 July 2007 Form 288(b) Terminating appointment of Director - Dr Paul Whitney 14 June 2007 Registration of resolutions passed at EGM and adoption of Articles of Association adopted at EGM 28 March 2007 Registration of resolutions passed at AGM 7 March 2007 Form 88(2) - Return of Allotment of Shares Copies of these documents can be obtained from Companies House, Crown Way, Cardiff CF14 3UZ (Telephone 0870 3333 636, email at enquiries @companies-house.gov.uk) or, if you are a registered user, through Companies House Direct at www.companies-house.gov.uk Copies of all documents referred to above are also available for inspection at the Company's registered office (Corpus Christi House, 9 West Street, Godmanchester, Cambs PE29 2HY, United Kingdom) during normal business hours or by request from the Company Secretary. For further information, please contact: Zoe McGowan, Company Secretary Phytopharm plc Tel No: +44 (0)1480 437697 Further information about Phytopharm can be found on the Company's website www.phytopharm.com This information is provided by RNS The company news service from the London Stock Exchange AFEFPPEFE

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